?SYNTHESIS OF SOME NEW NITROGENOUS DERIVATIVES OF GLYCYRRHETIC ACID WITH POTENTIAL BIOLOGICAL ACTIVITY

Authors

  • YEHIA ABDU IBRAHIM National Research Centre, Chern. of Microbial and Natural Products Dept., Dokki, Cairo, Egypt
  • ATEF G. HANNA National Research Centre, Chern. of Microbial and Natural Products Dept., Dokki, Cairo, Egypt
  • M. HANiA. ELGAMAL National Research Centre, Chern. of Microbial and Natural Products Dept., Dokki, Cairo, Egypt
  • R. F. ALLAM National Research Centre, Chern. of Microbial and Natural Products Dept., Dokki, Cairo, Egypt
  • KHALEDA. M. YOUSSEF National Research Centre, Chern. of Microbial and Natural Products Dept., Dokki, Cairo, Egypt

Keywords:

Glycyrrhetic acid, Oxadiazole, Triazole, Thiodiazole derivatives.

Abstract

The synthesis of some nitrogenous derivatives from glycyrrhetic acid hydrazides (III) by incorporating its C-30 to
form 1', 3', 4'-oxadiazole (V), 4'-acetyl-5-aryl-1'-oxadiazoline (VII), 1',3',4'-triazole (X), carboxymethyl thiotriazole
(XII) and 1',3',4'-thiodiazoline-5'-thion (XIII) rings are reported. The reactions of the hydrazide III with aromatic aldehydes,
thiocyanates, isocyanates and its 3-acetyl derivative (XVI) with aniline and ethyl glycinate were studied. The antimicrobial
activity of some derivatives was tested against some microorganisms.

Published

1995-05-22

Issue

Vol. 38 No. 3-4 (1995): Pakistan Journal of Scientific and Industrial Research

Section

Articles

How to Cite

?SYNTHESIS OF SOME NEW NITROGENOUS DERIVATIVES OF GLYCYRRHETIC ACID WITH POTENTIAL BIOLOGICAL ACTIVITY. (1995). Biological Sciences - PJSIR, 38(3-4), 101-107. https://www.v2.pjsir.org/index.php/biological-sciences/article/view/2447