SYNTHESIS OF SOME NEW PYRIMIDINE DERIVATIVES INCORPORATED INTO OTHER HETEROCYCLES FOR BIOLOGICAL EVALUATION

Authors

  • Afaf H El- Masry Therapeutical Chemistry Department,NRC,Dokki-12311, Cairo, Egypt

Keywords:

Chloroacetyl, Pyrimidine, Thioglycolic acid, Thiolactic acid, Thiadiazole, Thiosemicarbazide.

Abstract

Chloroacetyl pyrimidine was synthesized and reacted  with  both  aromatic  amines  and  hydrazine  hydrate.  Hydrazide was reacted with !3-dicarbonyl compounds and also with different acid anhydrides. 2-Amino-pyrimidine afforded new Schiff 's bases which were cyclized with thioglycolic acid and thiolactic acid . Thiosemicarbazido derivatives  were cyclized to give thiadiazole which gave Mannich bases. Some of the  newly  prepared  compounds  were  biologically tested  as antimicrobials

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Published

2002-04-22

Issue

Vol. 45 No. 2 (2002): Pakistan Journal of Scientific and Industrial Research

Section

Articles

How to Cite

SYNTHESIS OF SOME NEW PYRIMIDINE DERIVATIVES INCORPORATED INTO OTHER HETEROCYCLES FOR BIOLOGICAL EVALUATION. (2002). Biological Sciences - PJSIR, 45(2), 69-75. https://www.v2.pjsir.org/index.php/biological-sciences/article/view/1752