MICROBIAL SIDE - CHAIN DEGRADATIONOF PROGESTERONE II. APPLICATIONOF DIFFERENT TECHNIQUESFOR PROGESTERONE CONVERSIONBYFUSARIUMDIMERIUM

Authors

  • Nehad Z Adham Chemistry of Natural and Microbial Products Department, National Research Centre, Dokki, Giza, Egyp
  • Osama M El - Tayeb Microbiology Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt
  • Abdel - Gawad M Hashem Microbiology Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt
  • Heba El - Refai Chemistry of Natural and Microbial Products Department, National Research Centre, Dokki, Giza, Egyp
  • Lotfy A Sallam Chemistry of Natural and Microbial Products Department, National Research Centre, Dokki, Giza, Egyp

Keywords:

Fusarium dimerium, Progesterone, Bioconversion.

Abstract

A local isolate of Fusarium dimerium,  firstly reported to be able to degrade progesterone side chain to give certain C-19 androgenes derivatives, proved to perform this important conversion more efficiently adopting the cell immobilization technique. Thus, relatively more amounts of Androst - 4 - ene - 3, 17 - dione (AD), Testololactone (TL) (major products) as well as, Testosterone (T), Androsta - 1,4 - diene 3, 17 - dione (ADD) (minor products) were recorded after 72 h using 2 % Ca - alginate immobilized fungal cells. Relatively lower bioconversion rates were achieved when the bioconversion process was carried out in top - laboratory fermentor using free cells of the promising

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Published

2004-04-26

Issue

Vol. 47 No. 2 (2004): Pakistan Journal of Scientific and Industrial Research

Section

Articles

How to Cite

MICROBIAL SIDE - CHAIN DEGRADATIONOF PROGESTERONE II. APPLICATIONOF DIFFERENT TECHNIQUESFOR PROGESTERONE CONVERSIONBYFUSARIUMDIMERIUM. (2004). Biological Sciences - PJSIR, 47(2), 138-141. https://www.v2.pjsir.org/index.php/biological-sciences/article/view/1483